DR RICHARD BOGLE PHD FRCP FESC FACC DHMSA CONSULTANT CARDIOLOGIST
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Malaria therapy and the Horton Hospital in Epsom

26/2/2013

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In 1975 a simple ceremony was held at the Horton Hospital in Epsom. A plaque was unvieled commemorating the contribution made between 1925 and 1965 towards the "relief of suffering". The building housed the Mott Clinic also known as the Horton Malaria Laboratory. It was here, before the discovery of penicillin, that malaria infected mosquitos were used to treat patients with syphilis.

In Vienna at the end of world war one Professor Wagner-Jauregg dicovered that malaria-induced fever was effective in the treatment of the syphilitic condiiton General Paralysis of the Insane (GPI). GPI was a serious problem affecting about 10% of patients in psychiatric hospitals and there was until that time no effective treatment. The malaria therapy was reported to result in over 80% of patients were free of disease progression. The treatment was introduced rapidly into England but there was lack of awareness of the lethal effects of certain species of human malaria parasites such as Plasmodium falciparum. Horton was chosen to treat these patients because after a pilot study at Cane Hill and Claybury hospitals they found that there was a high risk that malaria would spread between patients; Horton was ideal because of the fourteen bed isolation hospital and so to try and render the treatment as safe as possible the Mott Clinic and Horton Laboratory was established. Colonel S. P. James, was the first director and he found a strain of malaria in Madagasca that was safe for use in man. In May 1925, mosquitoes infected with this strain were taken to Horton and fed on two female patients.The function of the laboratory was to provide malaria parasites use in the treatment of GPI and this continued until penicillin made the treatment obsolete. Overall the clinic provided treatment for thousands of patients sufferering from GPI with more than 16,000 treated in Horton Hospital itself.  A stream of publications appeared in scientific journals originating from the Horton Laboratory including the discovery of the exoerythrocytic parasite in the liver in man in 1948. The laboratory moved into the testing synthetic antimalarial drugs in conditions of maximum secrecy during the second world war. The laboratory closed in 1973 and its memorabilia and archives are held at the Wellcome Museum and the London School of Hygiene and Tropical Medicine.

Epsom and Ewell Archives


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Aerial view of Horton Hospital
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    Dr Richard Bogle

    The opinions expressed in this blog are strictly those of the author and should not be construed as the opinion or policy of my employers nor recommendations for your care or anyone else's. Always seek professional guidance instead.

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  • Home
  • Blog
  • NHS Practice
    • NHS Practice
    • St Helier Hospital
    • Epsom Cardiac Day Unit
    • St George's Hospital Radial Lounge
    • Echocardiography
  • Biography
    • Qualifications
    • About me >
      • Curriculum vitae
    • Appraisal and Revalidation
    • BCIS Angioplasty Audit
    • Publications
    • Recent abstracts
    • Research
    • Charitable activity
  • The Heart
    • Cardiac Investigations >
      • AliveCor ECG monitor
      • Guide to investigations for suspected angina
      • CT calcium scoring
      • Electrocardiogram (ECG)
      • Exercise treadmill test
      • Echocardiogram
      • Valve disease
      • Coronary Angiography
      • Pressure Wire Studies
      • Intra-vascular Ultrasound
    • Arrhythmias >
      • Atrial fibrillation >
        • Stroke Risk in AF
        • New Oral Anticoagulants
        • Presentations on AF
      • Atrial flutter
      • Pre-excitation syndromes
      • Ventricular ectopic beats
      • Ventricular arrhythmias
      • Pacemaker
      • DC Cardioversion
    • Cardiomyopathy
    • Coronary heart disease >
      • Cardiac syndrome X
      • Coronary Angioplasty
      • Coronary bypass surgery
    • Dizziness and blackouts
    • Fitness to fly
    • Fitness to drive
    • Heart Failure
    • Hypertension >
      • Patients guide to blood pressure medication
      • Home blood pressure monitors
      • Hypertension diet
      • Laragh's method
      • Renal sympathetic ablation for hypertension
      • Conn's Syndrome
    • Heart Screening >
      • Sports Cardiology
      • Cardiovascular Disease Risk
    • Medications >
      • Glyceryl trinitrate
    • Patient information leaflets
  • News and Links
  • Miscellany
    • History of Medicine
    • History of Coronary Angiography and Angioplasty
    • Stamps in Cardiology
    • A History of Medicine in 100 Objects
    • BSE Acceditation Course Introduction
    • BSE Acceditation Course Physics
    • BSE Acceditation Course Anatomy and Function
    • BSE Acceditation Course Mitral
    • BSE Acceditation Course Aortic
    • BSE Acceditation Course Congenital
    • BSE Acceditation Course Pericardium
    • RACPC Form
    • Cardiology Teaching St Helier Hospital